A pioneer biochemist, Carl Neuberg (1877-1956) spent over thirty years of his productive career as a professor at the University of Berlin (1903-1937) and as Director of the Kaiser Wilhelm Institutes of Biochemistry and Experimental Therapy. His varied research interests resulted in important contributions to the understanding of fermentation processes, solubility and transport phenomena in cells, the chemistry of carbohydrates, sugars, enzymes, and amino acids, and photochemistry. Neuberg was forced out of his position after the Nazi rise to power, and taking refuge in the United States. For the last several years of his life, he worked at New York University. The Neuberg collection consists of correspondence, lab notebooks, documents, photographs, and reprints, nearly all dating from after Neuberg's departure from Germany in 1940. The correspondence documents Neuberg's late-career work and the contacts he developed with American chemical manufacturers and industries involved in fermentation, as well as the burgeoning post-war relationship between scientific research and the federal dollar. Files for the American Cancer Society, U.S. Atomic Energy Commission, and the U.S. Public Health Service in particular contain useful information for study of the politics and mechanics of government grants.

For his pioneering research on the link between viruses and cancer, the pathologist Francis Peyton Rous was awarded the Nobel Prize in Medicine in 1966. Working primarily at the Rockefeller Institute after 1909, Rous first came to notice for his theoretical construction of the first blood bank for use in France during World War I, a plan ultimately implemented by his assistant, Oswald H. Robertson. Subsequently, he left an important imprint on the development of experimental medicine, partly through his own research on the origins of cancer and his administrative activities at the Rockefeller, but also as editor of the Journal of Experimental Medicine from 1921-1970. The Rous Papers include correspondence, lectures, articles, reports, laboratory records, reprints, and photographs that document all aspects of the life and work of Peyton Rous. Reflecting his work at the Institute are letters of colleagues, information on assistants, and reports to the directors (1909-1959). Additional material relates to Rous' diverse organizational interests, including the American Cancer Society, Century Association, Jane Coffin Childs Memorial Fund for Medical Research (at Yale University), Federation of American Societies for Experimental Biology, Johns Hopkins University, National Academy of Sciences, National Research Council, New York Academy of Medicine, Royal Society of Medicine Foundation, and Sloan-Kettering Institute for Cancer Research.

Working on bacterial viruses in 1945, Seymour S. Cohen offered the first systematic exploration of the biochemistry of virus-infected cells and of how viruses multiply. His subsequent research included delineating the phenomenon of thymineless death, developing derivatives of ara-A compound, working on RNA synthesis, studying the effects of polyamines on metabolic systems, and studying plant viruses (including viral cations). Much of his research has contributed to the chemical treatment of cancer and viral infections.

A biochemist at Columbia University, Erwin Chargaff discovered the base-pairing regularities or "complementarity relationships" of nucleic acids that provided one of the key steps in developing a structural model for DNA. During his long career, Chargaff is credited with conclusively falsifying the tetranucleotide hypothesis; demonstrating the existence of a large number of DNA species; and creating the first descriptions of hypochromicity, hyperchromicity, and the denaturation of a DNA. In addition, Chargaff conducted important research on blood coagulation, lipids and lipoproteins, the metabolism of amino acids and inositol, and the biosynthesis of phosphotransferases. He retired to emeritus status in 1974 and remained active in research almost to the time of his death in June 2002. The Chargaff Papers are organized into ten series: I. Correspondence, 1931-1992; Ia. Correspondence, 1949-2002; IIa. Grants, 1930-1982; IIb. Subject Files, 1940-1984; IIc. Subject Files, 1946-2002; III. Works by Chargaff, 1929-1989; IIIa. Works by Chargaff, 1923-2002; IIIb. Reprints, 1977-1999; IV. Works by Others, 1936-1985; IVa. Works by Others, 1976-2002; V. Research Notes and Notebooks, 1929-1951 ; VI. Photographs, 1935-1977; VIa. Photographs, 1928-2002; VII. Audiovisual Materials; VIII. Awards and Certificates, 1958-2001; IX. Lecture Notes, 1942-1985; X. Personal Papers, [1880]-1985.

A pathologist and cancer specialist, James B. Murphy (1884-1950) spent most of career associated with the Rockefeller Institute (1911-1950) investigating the role of lymphocytes in tuberculosis, x-ray mutagenesis, and the nature of malignant tumors in fowls. The Murphy Papers contains professional correspondence and research notes relating to James B. Murphy's cancer research at the Rockefeller, and information on several of the organizations to which he contributed or belonged, including the American Association for Cancer Research; American Bureau for Medical Aid to China; American Cancer Society; Bar Harbor Medical and Surgical Hospital; Roscoe B. Jackson Memorial Laboratory; Memorial Hospital for the Treatment of Cancer (New York City, ca. 1932-1950); National Advisory Cancer Council; and the New York Academy of Medicine (1923-1950). Murphy helped to develop mobile laboratories for hospitals in France during World War I.